Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.79 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.79 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.79 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.79 |
| ▸ | USP2 | O75604 | 1/20 | 0.79 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.79 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.79 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.79 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.79 |
| ▸ | ACE | P12821 | 1/20 | 0.79 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.79 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.79 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.79 |
| ▸ | PDE4A | P27815 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300503 | 0.95 | PPARG (0.72) | PPARGAGTR1AGTR2KDM4EABCC3 | |
| SCHEMBL7301976 | 0.93 | PPARG (0.68) | PPARGAGTR1AGTR2KDM4EABCC3 | |
| SCHEMBL7305793 | 0.93 | PPARG (0.68) | PPARGAGTR1AGTR2KDM4EABCC3 | |
| SCHEMBL7302995 | 0.93 | PPARG (0.68) | PPARGAGTR1AGTR2KDM4EABCC3 | |
| SCHEMBL7305469 | 0.93 | AGTR1 (0.68) | PPARGAGTR1AGTR2KDM4EABCC3 | |
| SCHEMBL7307117 | 0.93 | AGTR1 (0.68) | PPARGAGTR1AGTR2KDM4EABCC3 | |
| SCHEMBL4615513 | 0.91 | PPARG (0.72) | PPARGAGTR1AGTR2KDM4EABCC3 | |
| SCHEMBL8788417 | 0.90 | PPARG (0.64) | PPARGAGTR1AGTR2KDM4EABCC3 | |
| SCHEMBL7302777 | 0.90 | PPARG (0.65) | PPARGAGTR1AGTR2KDM4EABCC3 | |
| SCHEMBL9573016 | 0.90 | AGTR1 (0.63) | PPARGAGTR1AGTR2KDM4EABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0502314-B1 | Benzimidazol derivatives, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1998-05-20 | — | — | EP | claimed |
| EP-0502314-A1 | Benzimidazol, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-09 | — | — | EP | claimed |
| EP-2432452-B1 | PHARMACEUTICAL TELMISARTAN DRINK SOLUTION | BOEHRINGER INGELHEIM VETMED (DE) | 2016-07-27 | — | — | EP | disclosed |
| EP-2612658-A1 | Pharmaceutical compositions of 4'-[(1,4'dimethyl-2'-propyl[2,6'-bi-1h-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid and is 6-chloro-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide | Laboratorios Lesvi, S.L. (ES) | 2013-07-10 | — | — | EP | disclosed |
| EP-2432452-A1 | PHARMACEUTICAL ORAL TELMISARTAN SOLUTION | Boehringer Ingelheim Vetmedica GmbH (DE) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133638-A1 | PHARMACEUTICAL ORAL TELMISARTAN SOLUTION | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 2010-11-25 | — | — | WO | disclosed |
| EP-2176235-A2 | A METHOD OF MANUFACTURING 4'-[[4-METHYL-6-(1-METHYL-1H-BENZIMIDAZOL-2-YL)-2-PROPYL-1H-BENZIMIDAZOL-1YL]METHYL]BIPHENYL-2-CARBOXYLIC ACID (TELMISARTAN) | Zentiva, k.s. (CZ) | 2010-04-21 | — | — | EP | disclosed |
| EP-1014989-B1 | ENDOTHELIN ANTAGONIST AND A RENIN-ANGIOTENSIN SYSTEM INHIBITOR AS A COMBINED PREPARATION | ABBOTT GMBH & CO KG (DE) | 2004-01-14 | — | — | EP | disclosed |
| EP-0634175-B1 | Pharmaceutical combination, containing a renin-angiotensin-system inhibitor and an endothelin antagonist | HOFFMANN LA ROCHE (CH) | 2001-01-10 | — | — | EP | disclosed |
| EP-0502314-B1 | Benzimidazol derivatives, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1998-05-20 | — | — | EP | disclosed |
| EP-0634175-A1 | Pharmaceutical combination, containing a renin-angiotensin-system inhibitor and an endothelin antagonist | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-18 | — | — | EP | disclosed |
| EP-0502314-A1 | Benzimidazol, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-09 | — | — | EP | disclosed |