Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | PDE6D | O43924 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8378326 | 0.92 | PLG (0.35) | MAPTALDH1A1HSP90AA1KMT2AMEN1 | |
| SCHEMBL8374713 | 0.91 | KMT2A (0.31) | MAPTALDH1A1HSP90AA1KMT2AMEN1 | |
| SCHEMBL8378225 | 0.90 | MEN1 (0.35) | KMT2AMEN1HTR7 | |
| SCHEMBL8517515 | 0.89 | CCR3 (0.40) | KMT2AMEN1L3MBTL1 | |
| SCHEMBL8375935 | 0.86 | MAPT (0.38) | MAPTALDH1A1HSP90AA1KMT2AMEN1 | |
| SCHEMBL8517128 | 0.85 | MAPT (0.37) | MAPTALDH1A1HSP90AA1KMT2AMEN1 | |
| SCHEMBL8373704 | 0.85 | MAPT (0.40) | MAPTALDH1A1HSP90AA1KMT2AMEN1 | |
| SCHEMBL8378214 | 0.84 | MCHR1 (0.33) | KMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL8517142 | 0.81 | MAPT (0.38) | MAPTALDH1A1HSP90AA1KMT2AMEN1 | |
| SCHEMBL8518068 | 0.81 | HDAC3 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900199-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997041099-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-11-06 | — | — | WO | disclosed |