Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8377485 | 0.92 | ALDH1A1 (0.36) | MAPTALDH1A1HSP90AA1KMT2AKDM4E | |
| SCHEMBL8377056 | 0.91 | MEN1 (0.34) | KMT2AMEN1CHRM2HTR1AADRA2A | |
| SCHEMBL8517128 | 0.91 | MAPT (0.37) | MAPTALDH1A1HSP90AA1KMT2AKDM4E | |
| SCHEMBL8378710 | 0.90 | DRD3 (0.38) | ALDH1A1KMT2AMEN1CHRM2HTR1A | |
| SCHEMBL8518266 | 0.89 | DRD2 (0.41) | ALDH1A1KMT2AKDM4EMEN1CHRM2 | |
| SCHEMBL8375936 | 0.86 | KMT2A (0.39) | MAPTALDH1A1HSP90AA1KMT2AKDM4E | |
| SCHEMBL8518033 | 0.86 | MAPT (0.38) | MAPTALDH1A1HSP90AA1KMT2AKDM4E | |
| SCHEMBL8373737 | 0.83 | BCHE (0.33) | ADRA1ABCHE | |
| SCHEMBL8374698 | 0.83 | ALDH1A1 (0.36) | MAPTALDH1A1HSP90AA1KMT2AKDM4E | |
| SCHEMBL8377618 | 0.82 | S1PR5 (0.35) | ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900199-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-10 | — | — | EP | claimed |
| WO-1997041099-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-11-06 | — | — | WO | claimed |
| EP-0900199-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997041099-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-11-06 | — | — | WO | disclosed |