Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10238709 | 0.85 | ATM (0.56) | SYKATMKLK5CTSSCTSL | |
| SCHEMBL2736627 | 0.85 | ATM (0.56) | SYKATMKLK5CTSSCTSL | |
| SCHEMBL4372922 | 0.83 | KLK5 (0.50) | SYKATMKLK5CTSSCTSL | |
| SCHEMBL27796636 | 0.81 | KLK5 (0.63) | ATMKLK5CTSSCTSLCTSB | |
| SCHEMBL27502332 | 0.81 | KLK5 (0.63) | ATMKLK5CTSSCTSLCTSB | |
| SCHEMBL8486327 | 0.81 | KLK5 (0.63) | ATMKLK5CTSSCTSLCTSB | |
| SCHEMBL27486450 | 0.81 | KLK5 (0.63) | ATMKLK5CTSSCTSLCTSB | |
| SCHEMBL10188447 | 0.79 | ATM (0.56) | SYKATMKLK5CTSSCTSL | |
| SCHEMBL3604545 | 0.78 | MMP2 (0.58) | SYKATMKLK5CTSSCTSL | |
| SCHEMBL2548977 | 0.78 | MMP2 (0.58) | SYKATMKLK5CTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999059989-A1 | PROCESS FOR THE PREPARATION OF A BENZO FUSED HETEROCYCLO SULFONYL HALIDE INTERMEDIATE | G.D. SEARLE & CO. (US) | 1999-11-25 | — | — | WO | disclosed |