Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SI | P14410 | 1/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL29240223 | 0.96 | TP53 (0.44) | TP53MGAMGAASIMGAM2 | |
| Lactic Acid SCHEMBL28965397 | 0.94 | TP53 (0.42) | TP53MGAMGAASIMGAM2 | |
| Lactic Acid SCHEMBL28965381 | 0.89 | FFAR3 (0.45) | TP53MGAMGAASIMGAM2 | |
| SCHEMBL8596807 | 0.87 | MGAM (0.46) | MGAMGAASIMGAM2ALDH1A1 | |
| Lactic Acid SCHEMBL29124782 | 0.85 | TP53 (0.46) | TP53MGAMGAASIMGAM2 | |
| Alanine SCHEMBL27895350 | 0.85 | MGAM (0.44) | MGAMGAASIMGAM2ALDH1A1 | |
| Propionic Acid SCHEMBL29156529 | 0.84 | MGAM (0.40) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL31535869 | 0.83 | MGAM (0.43) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL5075 | 0.83 | — | — | |
| SCHEMBL27657786 | 0.83 | GAA (0.63) | MGAMGAASIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1339974-A | Wound closure material based on methylene malonate | VIRSOL CO (FR) | 2002-03-13 | — | — | CN | claimed |
| CN-101217940-B | Glp-1 analogue formulations | CAMURUS AB | 2013-03-27 | — | — | CN | disclosed |
| CN-101217940-A | GLP-1 analogue formulations | CAMURUS AB (SE) | 2008-07-09 | — | — | CN | disclosed |
| EP-0668073-B1 | Polyester matrix for a pharmaceutical sustained-release preparation | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-04-14 | — | — | EP | disclosed |
| US-5665394-A | Matrix for sustained-release preparation | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-09-09 | — | — | US | disclosed |
| US-5594091-A | POLYLACTONES FOR MICROCAPSULES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-14 | — | — | US | disclosed |
| EP-0668073-A2 | Polyester matrix for a pharmaceutical sustained-release preparation | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-08-23 | — | — | EP | disclosed |