Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL8518304 | 0.94 | TP53 (0.48) | TP53MGAMGAASIMGAM2 | |
| Propionic Acid SCHEMBL29156529 | 0.91 | MGAM (0.40) | MGAMGAASIMGAM2ALDH1A1 | |
| Lactic Acid SCHEMBL29240223 | 0.90 | TP53 (0.44) | TP53MGAMGAASIMGAM2 | |
| Propionic Acid SCHEMBL30223222 | 0.88 | GAA (0.52) | MGAMGAASIMGAM2ALDH1A1 | |
| Lactic Acid SCHEMBL28965381 | 0.87 | FFAR3 (0.45) | TP53MGAMGAASIMGAM2 | |
| Lactic Acid SCHEMBL28965404 | 0.82 | TP53 (0.44) | TP53MGAMGAASIMGAM2 | |
| SCHEMBL8596807 | 0.82 | MGAM (0.46) | MGAMGAASIMGAM2ALDH1A1 | |
| Lactic Acid SCHEMBL28965389 | 0.81 | TP53 (0.58) | TP53FFAR3CYP1A2 | |
| Glycolic Acid SCHEMBL28797546 | 0.81 | GAA (0.55) | MGAMGAASIMGAM2ALDH1A1 | |
| Propionic Acid SCHEMBL28965376 | 0.80 | FFAR3 (0.42) | TP53MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115745946-A | Low-temperature preparation method of glycolide-lactide | 中国科学院长春应用化学研究所 | 2023-03-07 | — | — | CN | disclosed |