Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.67 |
| ▸ | CA1 | P00915 | 2/20 | 0.67 |
| ▸ | CA2 | P00918 | 2/20 | 0.67 |
| ▸ | CA7 | P43166 | 2/20 | 0.67 |
| ▸ | CA9 | Q16790 | 2/20 | 0.67 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.67 |
| ▸ | CA3 | P07451 | 1/20 | 0.67 |
| ▸ | TYR | P14679 | 1/20 | 0.67 |
| ▸ | DRD1 | P21728 | 1/20 | 0.67 |
| ▸ | CA4 | P22748 | 1/20 | 0.67 |
| ▸ | CA6 | P23280 | 1/20 | 0.67 |
| ▸ | CA5A | P35218 | 1/20 | 0.67 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.67 |
| ▸ | RXRA | P19793 | 2/20 | 0.60 |
| ▸ | RXRB | P28702 | 2/20 | 0.60 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | USP5 | P45974 | 1/20 | 0.52 |
| ▸ | RXRG | P48443 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL28827747 | 0.92 | CA12 (0.56) | CA12CA1CA2CA7CA9 | |
| Benzoic Acid SCHEMBL6578872 | 0.92 | CA12 (0.56) | CA12CA1CA2CA7CA9 | |
| SCHEMBL105270 | 0.91 | RXRA (0.62) | CA12CA1CA2CA7CA9 | |
| Potassium SCHEMBL29478303 | 0.89 | RXRA (0.61) | CA12CA1CA2CA7CA9 | |
| Magnesium SCHEMBL31587750 | 0.89 | RXRA (0.61) | CA12CA1CA2CA7CA9 | |
| SCHEMBL30302279 | 0.89 | RXRA (0.61) | CA12CA1CA2CA7CA9 | |
| SCHEMBL30846833 | 0.89 | RXRA (0.61) | CA12CA1CA2CA7CA9 | |
| Hydrochloric Acid SCHEMBL7667894 | 0.89 | RXRA (0.61) | CA12CA1CA2CA7CA9 | |
| Calcium SCHEMBL31749038 | 0.89 | RXRA (0.61) | CA12CA1CA2CA7CA9 | |
| SCHEMBL9185162 | 0.89 | RXRA (0.61) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942626-A | REACTING A 5-HALO-SUBSTITUTED BENZOTRIAZOLE WITH A MERCAPTO COMPOUND IN THE PRESENCE OF A GROUP 1A METAL OR GROUP 2A COMPOUND FORMING 5-THIO-SUBSTITUTED 2H-BENZOTRIAZOLES HAVING ENHANCED ABSORBANCE AT LONGER WAVELENGTHS | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1999-08-24 | — | — | US | disclosed |
| US-5849821-A | Tris-aryl-s-triazines substituted with biphenylyl groups | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1998-12-15 | — | — | US | disclosed |
| US-5844025-A | 1,2-Bis-adducts of stable nitroxides with substituted ethylenes and stabilized compositions | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1998-12-01 | — | — | US | disclosed |
| US-5726309-A | ULTRAVIOLET RADIATION ABSORBERS; THERMAL STABILIZERS FOR POLYMER SUBSTRATES, ESPECIALLY AUTOMOTIVE COATINGS | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1998-03-10 | — | — | US | disclosed |
| US-5684070-A | FILM WITH TRIAZINE RESORCINOL COMPOUND STABILIZERS FOR RADIATION RESISTANCE | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |
| US-5681955-A | PHOTOSTABILITY OF POLYMERS | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 1997-10-28 | — | — | US | disclosed |
| US-5679794-A | ACTINIC LIGHT RESISTANCE, PROCESSING HEAT RESISTANCE | CIBA-GEIGY CORPORATION (US) | 1997-10-21 | — | — | US | disclosed |
| US-5675004-A | POLYMER STABILIZERS TO PROTECT AGAINST ACTINIC RADIATION COVERING MORE OF THE NEAR-UV SPECTRUM; DISCOLORATION INHIBITION; SYNERGISTIC EFFECT WITH HINDERED AMINES; ALKYD, ACRYLIC, URETHANE COATINGS | CIBA-GEIGY CORPORATION (US) | 1997-10-07 | — | — | US | disclosed |
| US-5030729-A | Stabilizing Polyolefins Against Oxidative, Thermal And-Or Light Induced Degradation | CIBA-GEIGY CORPORATION (US) | 1991-07-09 | — | — | US | disclosed |
| US-4927925-A | Piperidine compounds and their use as thermal stabilizers | CIBA-GEIGY CORPORATION (US) | 1990-05-22 | — | — | US | disclosed |
| US-4803234-A | Piperidine compounds and their use as anti-oxidative, light or thermal induced degradation agents | CIBA-GEIGY CORPORATION (US) | 1989-02-07 | — | — | US | disclosed |
| US-4751281-A | LIGHT, HEAT, AND OXIDATION STABILIZERS FOR POLYMERS | CIBA-GEIGY CORPORATION (US) | 1988-06-14 | — | — | US | disclosed |