Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10058227 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP1A2POLBCYP2C19CHRM2 | |
| SCHEMBL22543396 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP1A2POLBCYP2C19CHRM2 | |
| SCHEMBL16857331 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP1A2POLBCYP2C19CHRM2 | |
| SCHEMBL10058235 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP1A2POLBCYP2C19CHRM2 | |
| SCHEMBL16857333 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP1A2POLBCYP2C19CHRM2 | |
| SCHEMBL25271337 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP1A2POLBCYP2C19CHRM2 | |
| SCHEMBL17812928 | 0.91 | CHRM2 (0.45) | CYP3A4CYP1A2POLBCYP2C19CHRM2 | |
| SCHEMBL715773 | 0.91 | CHRM2 (0.45) | CYP3A4CYP1A2POLBCYP2C19CHRM2 | |
| SCHEMBL13066371 | 0.91 | CHRM2 (0.45) | CYP3A4CYP1A2POLBCYP2C19CHRM2 | |
| SCHEMBL18555624 | 0.87 | NR1H2 (0.42) | CYP3A4CHRM2CHRM1CHRM3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-11158146-A | — | — | None | — | — | JP | disclosed |
| CN-113072521-A | ROR gamma t inhibitor and application thereof in medicine | 广东东阳光药业有限公司 | 2021-07-06 | — | — | CN | disclosed |
| US-20170320884-A1 | HYDROXMETHYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-11-09 | — | — | US | disclosed |
| US-20170320884-A1 | HYDROXMETHYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-11-09 | — | — | US | disclosed |
| JP-H11158146-A | HYDROXYPIPERIDINE DERIVATIVE AND ITS PRODUCTION | TOKUYAMA CORP | 1999-06-15 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170320884-A1 | HYDROXMETHYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, OXTR | CYP3A4 3907/4885CYP1A2 2524/4885POLB 3987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.