Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 15/20 | 0.46 |
| ▸ | PGR | P06401 | 3/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10975133 | 0.89 | AR (0.47) | ARPGRPDK1PDK2PDK3 | |
| SCHEMBL8519767 | 0.81 | AR (0.38) | ARPGRPDK1PDK2PDK3 | |
| SCHEMBL10975698 | 0.73 | PDK1 (0.43) | ARPGRPDK1PDK2PDK3 | |
| SCHEMBL324996 | 0.72 | AR (0.57) | AR | |
| SCHEMBL11939273 | 0.70 | AR (0.42) | ARPGR | |
| SCHEMBL10984328 | 0.69 | AR (0.34) | ARPGRPDK1PDK2PDK3 | |
| SCHEMBL25197764 | 0.68 | AR (0.41) | ARPGR | |
| SCHEMBL10069178 | 0.68 | AR (0.41) | ARPGR | |
| SCHEMBL2968418 | 0.68 | AR (0.42) | ARPGR | |
| SCHEMBL8519255 | 0.67 | AR (0.36) | ARPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239776-A | Anti-androgenic amides | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-12-16 | — | — | US | claimed |
| EP-0002309-A2 | Acylanilides, process for their manufacture and pharmaceutical and veterinary compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-06-13 | — | — | EP | claimed |
| US-5994362-A | ADMINISTERING FINASTERIDE AND CASODEX | MERCK & CO., INC. (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0514056-A2 | Use of estrogens or antiandrogens for reversal of male sexual phenotype in poultry | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016233-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC CANCER CONTAINING A 5 ALPHA REDUCTASE INHIBITOR AND AN ANTIANDROGEN | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |
| US-4282218-A | ANTIANDROGENS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-08-04 | — | — | US | disclosed |
| US-4239776-A | Anti-androgenic amides | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-12-16 | — | — | US | disclosed |
| EP-0002309-A2 | Acylanilides, process for their manufacture and pharmaceutical and veterinary compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-06-13 | — | — | EP | disclosed |