Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | NR5A1 | Q13285 | 13/20 | 0.34 |
| ▸ | NR5A2 | O00482 | 10/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | ACP1 | P24666 | 1/20 | 0.30 |
| ▸ | CDC25B | P30305 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8518767 | 0.96 | SCD (0.37) | SCDNR5A1NR5A2MEN1KMT2A | |
| SCHEMBL7601556 | 0.91 | SCD (0.39) | SCDNR5A1NR5A2 | |
| SCHEMBL8518169 | 0.77 | CYP3A4 (0.36) | NR5A1NR5A2 | |
| SCHEMBL822308 | 0.69 | SCD (0.43) | SCDMEN1KMT2A | |
| Undecane SCHEMBL4575036 | 0.69 | TSHR (0.44) | MEN1KMT2A | |
| SCHEMBL2335039 | 0.68 | SCD (0.46) | SCDMEN1KMT2A | |
| SCHEMBL3802053 | 0.68 | SCD (0.64) | SCD | |
| SCHEMBL5346762 | 0.67 | SCD (0.47) | SCDMEN1KMT2A | |
| SCHEMBL678379 | 0.67 | MEN1 (0.42) | SCDMEN1KMT2A | |
| SCHEMBL20339953 | 0.67 | MEN1 (0.42) | SCDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743938-B1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 1999-04-21 | — | — | EP | disclosed |
| EP-0743938-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| WO-1995021817-A1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-08-17 | — | — | WO | disclosed |
| US-5393790-A | Diphenyl- or phenyl/pyridyl-substituted spiroheptenes, -octenes,-nonenes or -decenes; cyclooxygenase II inhibitors; side effect reduction; antipyretics; antiarthritic agents | G.D. SEARLE & CO. (US) | 1995-02-28 | — | — | US | disclosed |