Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.44 |
| ▸ | DRD4 | P21917 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30395273 | 0.84 | MTNR1A (0.54) | CHRM2CHRM4CHRM5CHRM1DRD2 | |
| SCHEMBL29058373 | 0.84 | MTNR1A (0.54) | CHRM2CHRM4CHRM5CHRM1DRD2 | |
| SCHEMBL30395009 | 0.84 | MTNR1A (0.54) | CHRM2CHRM4CHRM5CHRM1DRD2 | |
| SCHEMBL10816361 | 0.82 | CHRM2 (0.44) | CHRM2CHRM4CHRM5CHRM1DRD2 | |
| SCHEMBL8553144 | 0.81 | CHRM2 (0.43) | CHRM2CHRM4CHRM5CHRM1DRD2 | |
| SCHEMBL28240256 | 0.79 | MTNR1A (0.48) | CHRM2CHRM4CHRM5CHRM1DRD2 | |
| SCHEMBL8556209 | 0.78 | CHRM2 (0.43) | CHRM2CHRM4CHRM5CHRM1DRD2 | |
| SCHEMBL21081149 | 0.72 | MTNR1A (0.58) | CHRM2CHRM4CHRM5CHRM1DRD2 | |
| SCHEMBL28323374 | 0.71 | POLB (0.47) | CHRM2CHRM4CHRM1CHRM3MEN1 | |
| SCHEMBL8520039 | 0.71 | MTNR1A (0.48) | CHRM2CHRM4CHRM5CHRM1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937045-A1 | N-ARYL SUBSTITUTED TETRAHYDROQUINOLINES LIGANDS FOR RETINOID RECEPTORS HAVING AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE ACTIVITY | Allergan Sales, Inc. (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998019999-A1 | N-ARYL SUBSTITUTED TETRAHYDROQUINOLINES LIGANDS FOR RETINOID RECEPTORS HAVING AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE ACTIVITY | ALLERGAN SALES, INC. (US) | 1998-05-14 | — | — | WO | disclosed |