Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | TP53 | P04637 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FASN | P49327 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7156031 | 0.95 | MAPT (0.58) | NPC1TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7159607 | 0.92 | NPC1 (0.80) | NPC1TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8518781 | 0.89 | NPC1 (0.52) | NPC1TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7160902 | 0.86 | ALDH1A1 (0.49) | NPC1TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8520137 | 0.85 | NPC1 (0.56) | NPC1TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8520300 | 0.84 | NPC1 (0.48) | NPC1TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8520036 | 0.84 | KDM4E (0.48) | NPC1TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7154096 | 0.83 | NPC1 (0.65) | NPC1TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7159278 | 0.83 | NPC1 (0.43) | NPC1TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL7160138 | 0.81 | ALDH1A1 (0.46) | NPC1TP53MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927167-A1 | 2-PHENYL BENZIMIDAZOLE DERIVATIVES AS MCP-1 ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998006703-A1 | 2-PHENYL BENZIMIDAZOLE DERIVATIVES AS MCP-1 ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1998-02-19 | — | — | WO | disclosed |