Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2477171 | 0.87 | CYP2C19 (0.40) | CYP2C19ALDH1A1CYP2D6DPP4F2 | |
| Hydrochloric Acid SCHEMBL5492998 | 0.85 | CYP2C19 (0.39) | CYP2C19ALDH1A1CYP2D6TSHRHTR6 | |
| SCHEMBL1858357 | 0.79 | SRC (0.41) | CYP2C19SRCFAAHPRSS1PRSS2 | |
| SCHEMBL780336 | 0.78 | CYP2C19 (0.52) | CYP2C19SRCALDH1A1CYP2D6DPP4 | |
| SCHEMBL438263 | 0.77 | SRC (0.40) | CYP2C19SRCFAAHPRSS1PRSS2 | |
| Potassium SCHEMBL29685977 | 0.76 | CYP2C19 (0.50) | CYP2C19SRCALDH1A1CYP2D6DPP4 | |
| SCHEMBL9124179 | 0.76 | CYP2C19 (0.50) | CYP2C19SRCALDH1A1CYP2D6DPP4 | |
| SCHEMBL16149912 | 0.75 | SRC (0.39) | CYP2C19SRCFAAHPRSS1PRSS2 | |
| SCHEMBL13096280 | 0.75 | DPP4 (0.46) | SRCFAAHPRSS1PRSS2ELANE | |
| SCHEMBL3083627 | 0.75 | ALDH1A1 (0.41) | CYP2C19SRCFAAHPRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5942400-A | CLEAVING BETA-AMYLOID PRECURSOR PROTEIN WITH A PROTEASE IN THE PRESENCE OF TEST COMPOUNDS, QUANTITATIVE ANALYSIS OF CLEAVED PRODUCTS, SCREENING PROTEASE INHIBITORS AND TREATING DOWN'S SYNDROME AND ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 1999-08-24 | — | — | US | disclosed |