Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.40 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGAV | P06756 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437402 | 0.82 | POLB (0.46) | POLBGRIN2B | |
| SCHEMBL31722127 | 0.82 | POLB (0.55) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL26714275 | 0.82 | POLB (0.55) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9639986 | 0.81 | POLB (0.54) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL92404 | 0.80 | NR4A1 (0.50) | POLBITGB1 | |
| SCHEMBL14012812 | 0.80 | POLB (0.55) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12164616 | 0.80 | POLB (0.55) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8697857 | 0.80 | POLB (0.55) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8660402 | 0.80 | POLB (0.55) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3578965 | 0.80 | POLB (0.55) | POLBPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5914328-A | CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS | ABBOTT LABORATORIES (US) | 1999-06-22 | — | — | US | disclosed |