Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 2/20 | 0.47 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 2/20 | 0.36 |
| ▸ | TACR2 | P21452 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL8521646 | 1.00 | GHSR (0.47) | GHSRTACR1HRH3OPRK1TGM2 | |
| SCHEMBL2589574 | 0.96 | GHSR (0.50) | GHSRTACR1HRH3OPRK1TGM2 | |
| SCHEMBL2589571 | 0.96 | GHSR (0.50) | GHSRTACR1HRH3OPRK1TGM2 | |
| Hydrochloric Acid SCHEMBL8521498 | 0.95 | GHSR (0.49) | GHSRTACR1HRH3OPRK1TGM2 | |
| Hydrochloric Acid SCHEMBL8521496 | 0.95 | GHSR (0.49) | GHSRTACR1HRH3OPRK1TGM2 | |
| Trifluoroacetic Acid SCHEMBL8313703 | 0.87 | GHSR (0.44) | GHSRHRH3 | |
| Trifluoroacetic Acid SCHEMBL8311373 | 0.87 | GHSR (0.44) | GHSRHRH3 | |
| SCHEMBL8522337 | 0.83 | GHSR (0.40) | GHSRTACR1HRH3TGM2SIGMAR1 | |
| SCHEMBL8522338 | 0.83 | GHSR (0.40) | GHSRTACR1HRH3TGM2SIGMAR1 | |
| SCHEMBL5050565 | 0.82 | GHSR (0.68) | GHSRTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5578593-A | RELEASING GROWTH HORMONES FOR ANIMALS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |