SCHEMBL8522216

SCHEMBL8522216

CCCCC[C@H]1CC[C@H]([Si@H]2CC[C@H](CCc3cc(F)c(F)c(F)c3)CC2)CC1

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
CYP3A4 P08684 1/20 0.31
CYP2C8 P10632 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
S1PR3 Q99500 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8522210 1.00 MEN1 (0.32) MEN1KMT2ACYP3A4CYP2C8CYP2D6
SCHEMBL8522215 1.00 MEN1 (0.32) MEN1KMT2ACYP3A4CYP2C8CYP2D6
SCHEMBL7766217 0.95 PTGS2 (0.33) CYP3A4CYP2C8CYP2D6CYP2C9CYP2C19
SCHEMBL7766209 0.95 PTGS2 (0.33) CYP3A4CYP2C8CYP2D6CYP2C9CYP2C19
SCHEMBL7766223 0.95 PTGS2 (0.33) CYP3A4CYP2C8CYP2D6CYP2C9CYP2C19
SCHEMBL8522651 0.91
SCHEMBL8522648 0.91
SCHEMBL8522654 0.91
SCHEMBL9763949 0.89 MEN1 (0.37) MEN1KMT2ACYP3A4CYP2C8CYP2D6
SCHEMBL7917379 0.89 MEN1 (0.37) MEN1KMT2ACYP3A4CYP2C8CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5951913-A Liquid crystal compositions comprising silacyclohexane compounds SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-09-14 US disclosed
US-5851426-A Twisted nematic liquid crystal composition containing a silacyclohexane compound SHIN-ETSU CHEMICAL CO., LTD. (JP) 1998-12-22 US disclosed