Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.75 |
| ▸ | IP6K1 | Q92551 | 8/20 | 0.57 |
| ▸ | IP6K3 | Q96PC2 | 5/20 | 0.57 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4203914 | 0.91 | IP6K1 (0.66) | PARP1IP6K1IP6K3IP6K2CHEK1 | |
| SCHEMBL29701199 | 0.87 | PARP1 (1.00) | PARP1IP6K1IP6K3IP6K2CHEK1 | |
| SCHEMBL216176 | 0.87 | PARP1 (1.00) | PARP1IP6K1IP6K3IP6K2CHEK1 | |
| SCHEMBL19144228 | 0.79 | PARP1 (0.58) | PARP1IP6K1IP6K3IP6K2CHEK1 | |
| SCHEMBL8522251 | 0.78 | PARP1 (0.43) | PARP1 | |
| SCHEMBL144026 | 0.74 | PARP1 (0.74) | PARP1IP6K1IP6K3IP6K2CHEK1 | |
| SCHEMBL18642662 | 0.71 | IP6K1 (0.41) | IP6K1IP6K3IP6K2 | |
| SCHEMBL8622180 | 0.70 | ACVR1 (0.73) | PARP1IP6K1IP6K3CHEK1PIM1 | |
| SCHEMBL11134 | 0.69 | PRKCI (0.53) | — | |
| SCHEMBL29424823 | 0.69 | PRKCI (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912559-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1998002434-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 1998-01-22 | — | — | WO | disclosed |