Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 1/20 | 0.76 |
| ▸ | HPRT1 | P00492 | 6/20 | 0.70 |
| ▸ | PNP | P00491 | 11/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL489056 | 0.99 | TK1 (0.74) | TK1HPRT1PNPKMT2A | |
| SCHEMBL6272299 | 0.99 | TK1 (0.74) | TK1HPRT1PNPKMT2A | |
| SCHEMBL22571178 | 0.99 | TK1 (0.74) | TK1HPRT1PNPKMT2A | |
| SCHEMBL8536007 | 0.99 | TK1 (0.74) | TK1HPRT1PNPKMT2A | |
| Hydrochloric Acid SCHEMBL258897 | 0.97 | TK1 (0.73) | TK1HPRT1PNPKMT2A | |
| SCHEMBL6272731 | 0.96 | TK1 (0.74) | TK1HPRT1PNP | |
| Phosphonic Acid SCHEMBL28142169 | 0.93 | TK1 (0.70) | TK1HPRT1PNP | |
| SCHEMBL667796 | 0.90 | TK1 (0.69) | TK1HPRT1PNP | |
| SCHEMBL8196749 | 0.88 | TK1 (0.78) | TK1HPRT1PNP | |
| SCHEMBL29286376 | 0.87 | TK1 (0.76) | TK1HPRT1PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116234585-A | Microtubule-associated protein TAU (MAPT) iRNA agent compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-115298312-A | Leucine-rich repeat kinase 2 (LRRK 2) iRNA agent compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2022-11-04 | — | — | CN | disclosed |
| CN-114796255-A | Application of nicotinamide mononucleotide in protecting liver from being damaged | 深圳市旷逸生物科技有限公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-114728018-A | Huntington (HTT) iRNA pharmaceutical compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2022-07-08 | — | — | CN | disclosed |
| US-10774366-B2 | Method of making polynucleotides using closed-loop verification | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-09-15 | — | — | US | disclosed |
| CN-110218727-A | For treating the exon skipping composition of muscular dystrophy | 萨勒普塔医疗公司 | 2019-09-10 | — | — | CN | disclosed |
| CN-110066793-A | For treating amyotrophic exon skipping composition | 萨勒普塔医疗公司 | 2019-07-30 | — | — | CN | disclosed |
| CN-105378081-B | Exon skipping compositions for the treatment of muscular dystrophy | 萨勒普塔医疗公司 | 2019-06-14 | — | — | CN | disclosed |
| CN-105392884-B | Exon skipping compositions for the treatment of muscle atrophy | 萨勒普塔医疗公司 | 2018-11-30 | — | — | CN | disclosed |
| WO-2015031381-A1 | CYCLOSPORIN ANALOGUES FOR PREVENTING OR TREATING HEPATITIS C | ENANTA PHARMACEUTICALS, INC. (US) | 2015-03-05 | — | — | WO | disclosed |
| CN-1321999-C | Novel phosphorus-containing prodrugs | METABASIS THERAPEUTICS INC (US) | 2007-06-20 | — | — | CN | disclosed |
| CN-1733779-A | Novel phosphorus-containing prodrug | METABASIS THERAPEUTICS INC (US) | 2006-02-15 | — | — | CN | disclosed |
| CN-1353719-A | Novel phosphorus-containing prodrugs | METABASIS THERAPEUTICS INC (US) | 2002-06-12 | — | — | CN | disclosed |
| EP-0704445-B1 | Preparation of N-9 substituted guanine compounds | HOFFMANN LA ROCHE (CH) | 1999-04-21 | — | — | EP | disclosed |
| US-5565565-A | Preparation of N-9 substituted guanine compounds | SYNTEX (U.S.A.) INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0704445-A1 | Preparation of N-9 substituted guanine compounds | F. Hoffmann-La Roche AG (CH) | 1996-04-03 | — | — | EP | disclosed |
| EP-0590361-A1 | Process for the preparation of 2-amino-6-halopurines | BASF Aktiengesellschaft (DE) | 1994-04-06 | — | — | EP | disclosed |
| US-4914131-A | HERPES SIMPLEX VIRUS; LIDOCAINE OR ITS SALTS | Brigham, Dana P. (US) | 1990-04-03 | — | — | US | disclosed |
| US-4757088-A | Administering lidocaine and pantothenic acid; herpes | Brigham, Dana P. (US) | 1988-07-12 | — | — | US | disclosed |
| US-4628063-A | LIDOCAINE, PANTOTHENOL, HERPES | Brigham, Dana P. (US) | 1986-12-09 | — | — | US | disclosed |