Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Phenytoin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.79 |
| ▸ | SCN4A known ✓ | P35499 | 1/20 | 0.79 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.79 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.79 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.79 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | MAPT | P10636 | 1/20 | 0.79 |
| ▸ | HTR2A | P28223 | 1/20 | 0.79 |
| ▸ | HRH1 | P35367 | 1/20 | 0.79 |
| ▸ | BLM | P54132 | 1/20 | 0.79 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.79 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.79 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.79 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.79 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenytoin SCHEMBL3440 | 0.89 | CYP2C9 (1.00) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| Phenytoin SCHEMBL5499612 | 0.89 | CYP2C9 (1.00) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| Phenytoin SCHEMBL28905600 | 0.87 | CYP2C9 (0.88) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| Phenytoin SCHEMBL2905857 | 0.87 | CYP2C9 (0.96) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| Phenytoin SCHEMBL5160618 | 0.87 | CYP2C9 (0.96) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| Phenytoin SCHEMBL2140317 | 0.87 | CYP2C9 (0.96) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| Phenytoin SCHEMBL1461588 | 0.87 | CYP2C9 (0.96) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| Phenytoin SCHEMBL10406406 | 0.87 | CYP2C9 (0.96) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| Phenytoin SCHEMBL157671 | 0.87 | CYP2C9 (0.96) | CYP2C9CACNA1FALDH1A1MAPTHTR2A | |
| Phenytoin SCHEMBL29521348 | 0.87 | CYP2C9 (0.96) | CYP2C9CACNA1FALDH1A1MAPTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866671-A | ACETAL RESIN, HYDANTOIN OR IMIDAZOLE DERIVATIVE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1999-02-02 | — | — | US | disclosed |