Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 11/20 | 0.60 |
| ▸ | RARB | P10826 | 6/20 | 0.60 |
| ▸ | RXRB | P28702 | 6/20 | 0.60 |
| ▸ | RARG | P13631 | 5/20 | 0.60 |
| ▸ | RXRG | P48443 | 4/20 | 0.60 |
| ▸ | RARA | P10276 | 4/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.49 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 7/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9746735 | 0.89 | RARB (0.63) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL10355822 | 0.85 | RXRA (0.56) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL10355823 | 0.83 | CYP3A4 (0.43) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL10356133 | 0.83 | CYP26A1 (0.45) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL10356205 | 0.83 | RXRA (0.43) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL8949891 | 0.82 | CDC25B (0.55) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL10458111 | 0.81 | CDC25B (0.54) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL10356204 | 0.81 | AKR1C3 (0.46) | RXRARARBRXRBRARGRXRG | |
| SCHEMBL8776432 | 0.80 | RARB (0.63) | RXRARARBRARGRARACYP26A1 | |
| SCHEMBL8776390 | 0.80 | RXRA (0.44) | RXRARARBRXRBRARGRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260162-B1 | BICYCLIC AROMATIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA Groupement d'Intérêt Economique dit: (FR) | 1990-11-14 | — | — | EP | claimed |
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |
| US-4833240-A | SKIN DISORDERS; ANTIINFLAMMATORY AGENTS; ANTIALLLERGENS; ANTITUMOR AGENTS; OPHTHALMOLOGY | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1989-05-23 | — | — | US | disclosed |