Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14877644 | 0.69 | LRRK2 (0.44) | LRRK2SYKGRM4IRAK4PDE4A | |
| SCHEMBL5787986 | 0.69 | BRD4 (0.35) | CRHR1IRAK4PDE4APDE4B | |
| SCHEMBL5787990 | 0.69 | BRD4 (0.35) | CRHR1IRAK4PDE4APDE4B | |
| SCHEMBL15086908 | 0.65 | LRRK2 (0.49) | LRRK2SYK | |
| SCHEMBL8277618 | 0.65 | LRRK2 (0.49) | LRRK2SYK | |
| SCHEMBL6305307 | 0.65 | CRHR1 (0.46) | CRHR1PDE4APDE4B | |
| SCHEMBL5788374 | 0.65 | IRAK4 (0.37) | LRRK2CRHR1IRAK4 | |
| SCHEMBL5599539 | 0.65 | IRAK4 (0.37) | LRRK2CRHR1IRAK4 | |
| SCHEMBL6634034 | 0.64 | SYK (0.38) | LRRK2SYKPDE4APDE4B | |
| SCHEMBL24498739 | 0.63 | SYK (0.46) | SYKPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923582-A1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008847-A1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1998-03-05 | — | — | WO | disclosed |