Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8457160 | 0.83 | HDAC9 (0.43) | MTNR1AMTNR1BHDAC9IDO1TDO2 | |
| SCHEMBL18088738 | 0.81 | MTNR1A (0.41) | POLBRAB9ANAMPTMTNR1AMTNR1B | |
| SCHEMBL27880909 | 0.75 | KDM1A (0.41) | HDAC9KDM1A | |
| SCHEMBL7452148 | 0.74 | KDM4E (0.41) | POLBHDAC9MAPTKDM1AMEN1 | |
| SCHEMBL10637900 | 0.73 | KDM1A (0.46) | HDAC9KDM1AMEN1KMT2A | |
| SCHEMBL20137427 | 0.71 | HDAC9 (0.40) | POLBHDAC9MAPTLMNAMEN1 | |
| SCHEMBL20137426 | 0.71 | HDAC9 (0.40) | POLBHDAC9MAPTLMNAMEN1 | |
| SCHEMBL17963540 | 0.70 | KDM1A (0.61) | MTNR1AMTNR1BKDM1A | |
| SCHEMBL5807645 | 0.70 | KDM1A (0.40) | KDM1AMEN1KMT2A | |
| SCHEMBL18088743 | 0.70 | MTNR1A (0.44) | RAB9AMTNR1AMTNR1BHDAC9GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880159-A | TREATING ACUTE NEUROLOGICAL TRAUMATIC DISORDER OR NEUROTRAUMA | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1999-03-09 | — | — | US | disclosed |
| US-5639913-A | TREATMENT OF PARKINSON'S DISEASE, DEMENTIA, EPILEPSY | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1997-06-17 | — | — | US | disclosed |