SCHEMBL852352

SCHEMBL852352

Cc1cccc2ncccc12.[Sn]

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.56
KDM4E B2RXH2 1/20 0.56
CYP1A2 P05177 2/20 0.50
CYP2A6 P11509 2/20 0.50
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
POLB P06746 1/20 0.47
HTT P42858 2/20 0.46
PSMD14 O00487 1/20 0.46
COPS5 Q92905 1/20 0.46
SLC6A2 P23975 1/20 0.46
CYP3A4 P08684 1/20 0.45
HSP90AA1 P07900 2/20 0.45
NOS3 P29474 1/20 0.45
NOS1 P29475 1/20 0.45
NOS2 P35228 1/20 0.45
NPC1 O15118 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
LMNA P02545 2/20 0.44
HSP90AB1 P08238 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL129944 0.98 MAPT (0.58) MAPTKDM4ECYP1A2CYP2A6MEN1
Hydrogen Sulfide SCHEMBL27577867 0.96 MAPT (0.56) MAPTKDM4ECYP1A2CYP2A6MEN1
SCHEMBL27598199 0.96 MAPT (0.56) MAPTKDM4ECYP1A2CYP2A6MEN1
Hydrogen Sulfide SCHEMBL27503867 0.94 MAPT (0.54) MAPTKDM4ECYP1A2CYP2A6MEN1
Hydrogen Sulfide SCHEMBL27488502 0.94 MAPT (0.54) MAPTKDM4ECYP1A2CYP2A6MEN1
Hydrogen Sulfide SCHEMBL27561977 0.94 MAPT (0.54) MAPTKDM4ECYP1A2CYP2A6MEN1
Hydrogen Sulfide SCHEMBL27489153 0.94 MAPT (0.54) MAPTKDM4ECYP1A2CYP2A6MEN1
Oxirane SCHEMBL827148 0.88 KDM4E (0.48) MAPTKDM4ECYP1A2CYP2A6MEN1
SCHEMBL29578471 0.82 NCF1 (0.56) MAPTKDM4ECYP1A2CYP2A6PSMD14
SCHEMBL31559 0.82 NCF1 (0.56) MAPTKDM4ECYP1A2CYP2A6PSMD14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1326984-B1 CYTOCHROME P450 MONOOXYGENASES CONSISTING OF THERMOPHILIC BACTERIA BASF SE (DE) 2012-03-28 EP disclosed