Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 2/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9245352 | 0.89 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAHPGDALOX12 | |
| SCHEMBL88005 | 0.86 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2LMNAHPGDALOX12 | |
| SCHEMBL9487265 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAHPGDALOX12 | |
| SCHEMBL9487258 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAHPGDALOX12 | |
| Hydrochloric Acid SCHEMBL2141106 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAHPGDALOX12 | |
| SCHEMBL8845450 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAHPGDALOX12 | |
| SCHEMBL2543501 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAHPGDALOX12 | |
| SCHEMBL8985064 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAHPGDALOX12 | |
| SCHEMBL1922708 | 0.82 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2LMNAHPGDALOX12 | |
| SCHEMBL3840012 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450513-B1 | Polymeric composition comprising transient foam control reagent | DOW CHEMICAL CO (US) | 1999-10-27 | — | — | EP | disclosed |
| US-5189071-A | Reduced polymer melt viscosity; nonmiscible with solid polymer | THE DOW CHEMICAL COMPANY (US) | 1993-02-23 | — | — | US | disclosed |
| US-5189072-A | Low density foams with good compressive strength | THE DOW CHEMICAL COMPANY (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0450513-A1 | Polymeric composition comprising transient foam control reagent | THE DOW CHEMICAL COMPANY (US) | 1991-10-09 | — | — | EP | disclosed |