Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8343995 | 0.89 | SOAT1 (0.40) | SOAT1EPHX1ALDH1A1HTTKMT2A | |
| SCHEMBL8338345 | 0.85 | SOAT1 (0.36) | SOAT1ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL8339153 | 0.83 | SOAT1 (0.38) | SOAT1EPHX1ALDH1A1HTTKMT2A | |
| SCHEMBL8338759 | 0.82 | KMT2A (0.35) | SOAT1KMT2AMEN1POLB | |
| SCHEMBL8344256 | 0.78 | SOAT1 (0.43) | SOAT1MAPK1ALDH1A1HTTKMT2A | |
| SCHEMBL8343161 | 0.75 | SOAT1 (0.45) | SOAT1ALDH1A1POLB | |
| SCHEMBL9001010 | 0.74 | SOAT1 (0.43) | SOAT1ALDH1A1HTTKMT2AMEN1 | |
| SCHEMBL8340881 | 0.71 | TP53 (0.47) | SOAT1 | |
| SCHEMBL8322248 | 0.71 | SOAT1 (0.49) | SOAT1ALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL8345165 | 0.71 | TP53 (0.46) | SOAT1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001860-A | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1999-12-14 | — | — | US | claimed |
| US-6001860-A | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1999-12-14 | — | — | US | disclosed |
| WO-1993024458-A1 | NEW N-ARYL AND N-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1993-12-09 | — | — | WO | disclosed |