Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | EEF2K | O00418 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MARK3 | P27448 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000419 | 0.81 | SOAT1 (0.41) | SOAT1LMNANTRK1MEN1KMT2A | |
| SCHEMBL9000628 | 0.78 | SOAT1 (0.45) | SOAT1LMNAHTTCDK2CDK5 | |
| SCHEMBL9000550 | 0.77 | SORT1 (0.40) | SOAT1LMNANTRK1KMT2A | |
| SCHEMBL8344256 | 0.77 | SOAT1 (0.43) | SOAT1LMNAHTTL3MBTL1ALDH1A1 | |
| SCHEMBL6284260 | 0.77 | ALDH1A1 (0.46) | SOAT1HTTALDH1A1MEN1KMT2A | |
| SCHEMBL32667998 | 0.76 | CYP1A2 (0.50) | SOAT1L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL9000743 | 0.75 | SOAT1 (0.38) | SOAT1MEN1KMT2ARAB9AGAA | |
| SCHEMBL9000766 | 0.75 | SOAT1 (0.38) | SOAT1MEN1KMT2AHPGD | |
| SCHEMBL9000670 | 0.74 | SOAT1 (0.39) | SOAT1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9000682 | 0.74 | SOAT1 (0.40) | SOAT1ALDH1A1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |