Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 15/20 | 0.84 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.84 |
| ▸ | HTR2C | P28335 | 10/20 | 0.84 |
| ▸ | DRD2 | P14416 | 6/20 | 0.84 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8524973 | 0.92 | HTR2A (1.00) | HTR2AKCNH2HTR2CDRD2HDAC1 | |
| SCHEMBL8525019 | 0.84 | HTR2A (1.00) | HTR2AKCNH2HTR2CDRD2 | |
| SCHEMBL8525084 | 0.81 | HTR2A (1.00) | HTR2AKCNH2HTR2CDRD2HDAC1 | |
| SCHEMBL10725147 | 0.80 | KCNH2 (0.78) | HTR2AKCNH2HTR2CDRD2HDAC1 | |
| SCHEMBL7955758 | 0.79 | HTR2A (1.00) | HTR2AKCNH2HTR2CDRD2HDAC1 | |
| SCHEMBL724548 | 0.78 | HDAC1 (1.00) | HTR2AKCNH2HTR2CDRD2HDAC1 | |
| SCHEMBL724547 | 0.78 | HDAC1 (1.00) | HTR2AKCNH2HTR2CDRD2HDAC1 | |
| SCHEMBL725442 | 0.77 | KCNH2 (0.72) | HTR2AKCNH2HTR2CDRD2HDAC1 | |
| SCHEMBL8524411 | 0.76 | HTR2A (0.81) | HTR2AKCNH2HTR2CDRD2 | |
| SCHEMBL8525408 | 0.74 | HTR2A (1.00) | HTR2AKCNH2HTR2CDRD2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999047511-A1 | INDOLE DERIVATIVES AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1999-09-23 | — | — | WO | disclosed |