Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 15/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 13/20 | 1.00 |
| ▸ | HTR2C | P28335 | 10/20 | 1.00 |
| ▸ | DRD2 | P14416 | 5/20 | 1.00 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8524411 | 0.89 | HTR2A (0.81) | HTR2AKCNH2HTR2CDRD2MAPK13 | |
| SCHEMBL8524319 | 0.80 | HTR2A (1.00) | HTR2AKCNH2HTR2CDRD2 | |
| SCHEMBL8525019 | 0.78 | HTR2A (1.00) | HTR2AKCNH2HTR2CDRD2 | |
| SCHEMBL8523885 | 0.75 | HTR2A (1.00) | HTR2AKCNH2HTR2CDRD2 | |
| SCHEMBL22778149 | 0.72 | KCNH2 (0.55) | HTR2AKCNH2HTR2CDRD2MAPK13 | |
| SCHEMBL8524501 | 0.71 | HTR2A (0.85) | HTR2AKCNH2HTR2CDRD2 | |
| SCHEMBL8525587 | 0.71 | HTR2A (0.83) | HTR2AKCNH2HTR2CDRD2 | |
| SCHEMBL25305280 | 0.70 | HTR3A (0.53) | HTR2AKCNH2HTR2CDRD2MAPK13 | |
| SCHEMBL2145333 | 0.70 | HTR3A (0.53) | HTR2AKCNH2HTR2CDRD2MAPK13 | |
| SCHEMBL24127465 | 0.70 | HTR3A (0.53) | HTR2AKCNH2HTR2CDRD2MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999047511-A1 | INDOLE DERIVATIVES AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1999-09-23 | — | — | WO | claimed |
| WO-1999047511-A1 | INDOLE DERIVATIVES AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1999-09-23 | — | — | WO | disclosed |