Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 8/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29478512 | 0.87 | KDM1A (0.57) | KDM1ASRCKITKDM4EMAP2K1 | |
| SCHEMBL829762 | 0.87 | KDM1A (0.57) | KDM1ASRCKITKDM4EMAP2K1 | |
| SCHEMBL1734721 | 0.87 | KDM1A (0.57) | KDM1ASRCKITKDM4EMAP2K1 | |
| SCHEMBL29478513 | 0.87 | KDM1A (0.57) | KDM1ASRCKITKDM4EMAP2K1 | |
| Hydrochloric Acid SCHEMBL27988356 | 0.86 | KDM1A (0.56) | KDM1ASRCKITKDM4EMAP2K1 | |
| Hydrochloric Acid SCHEMBL4378504 | 0.86 | KDM1A (0.56) | KDM1ASRCKITKDM4EMAP2K1 | |
| SCHEMBL8526204 | 0.84 | EGFR (0.53) | KDM1ASRCKITKDM4EAURKA | |
| SCHEMBL7209967 | 0.84 | KDR (0.52) | KDM1ASRCKDM4EMAP2K1AURKA | |
| SCHEMBL6244778 | 0.81 | KDM1A (0.51) | KDM1ASRCKITKDM4EMAP2K1 | |
| SCHEMBL6244776 | 0.81 | KDM1A (0.51) | KDM1ASRCKITKDM4EMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |