Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 7/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 4/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29478512 | 0.95 | KDM1A (0.57) | KDREPHB4KDM1AEGFRFGFR1 | |
| SCHEMBL1734721 | 0.95 | KDM1A (0.57) | KDREPHB4KDM1AEGFRFGFR1 | |
| SCHEMBL29478513 | 0.95 | KDM1A (0.57) | KDREPHB4KDM1AEGFRFGFR1 | |
| SCHEMBL829762 | 0.95 | KDM1A (0.57) | KDREPHB4KDM1AEGFRFGFR1 | |
| Hydrochloric Acid SCHEMBL27988356 | 0.94 | KDM1A (0.56) | KDREPHB4KDM1AEGFRFGFR1 | |
| Hydrochloric Acid SCHEMBL4378504 | 0.94 | KDM1A (0.56) | KDREPHB4KDM1AEGFRFGFR1 | |
| SCHEMBL4986709 | 0.93 | SRC (0.54) | KDREPHA2EPHB4KDM1AEGFR | |
| SCHEMBL5498950 | 0.90 | EHMT2 (0.54) | KDREPHA2EPHB4EGFRFGFR1 | |
| SCHEMBL4380551 | 0.89 | EHMT2 (0.53) | KDREPHA2EPHB4EGFRFGFR1 | |
| SCHEMBL7215157 | 0.89 | EGFR (0.48) | KDREGFRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |