Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8021840 | 0.99 | HDAC3 (0.55) | HDAC3HDAC1HDAC2NCOR2L3MBTL1 | |
| SCHEMBL7983340 | 0.93 | HDAC1 (0.53) | HDAC3HDAC1HDAC2NCOR2L3MBTL1 | |
| SCHEMBL7973240 | 0.93 | HDAC1 (0.53) | HDAC3HDAC1HDAC2NCOR2L3MBTL1 | |
| SCHEMBL6378615 | 0.92 | HDAC1 (0.52) | HDAC3HDAC1HDAC2NCOR2L3MBTL1 | |
| SCHEMBL5737640 | 0.92 | HDAC1 (0.54) | HDAC3HDAC1HDAC2NCOR2L3MBTL1 | |
| SCHEMBL5738539 | 0.90 | HDAC3 (0.53) | HDAC3HDAC1HDAC2NCOR2L3MBTL1 | |
| SCHEMBL13617413 | 0.90 | HDAC3 (0.53) | HDAC3HDAC1HDAC2NCOR2L3MBTL1 | |
| SCHEMBL6379732 | 0.90 | HDAC1 (0.53) | HDAC3HDAC1HDAC2NCOR2L3MBTL1 | |
| SCHEMBL1848202 | 0.90 | HDAC1 (0.52) | HDAC3HDAC1HDAC2NCOR2L3MBTL1 | |
| SCHEMBL7203904 | 0.90 | BCHE (0.55) | HDAC3HDAC1HDAC2NCOR2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686142-B1 | POLYAMINE DERIVATIVES AS RADIOPROTECTIVE AGENTS | MERRELL PHARMA INC (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0399519-B1 | Potentiating cell-mediated immunity utilizing polyamine derivatives | MERRELL PHARMA INC (US) | 1996-08-07 | — | — | EP | disclosed |
| EP-0277635-B1 | Novel polyamine derivatives | MERRELL DOW PHARMA (US) | 1994-01-05 | — | — | EP | disclosed |