Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.57 |
| ▸ | SRC | P12931 | 9/20 | 0.56 |
| ▸ | KDR | P35968 | 8/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.56 |
| ▸ | KIT | P10721 | 3/20 | 0.56 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.56 |
| ▸ | LCK | P06239 | 3/20 | 0.56 |
| ▸ | RET | P07949 | 3/20 | 0.56 |
| ▸ | MET | P08581 | 3/20 | 0.56 |
| ▸ | LTK | P29376 | 3/20 | 0.56 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.56 |
| ▸ | FYN | P06241 | 2/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.56 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.56 |
| ▸ | BTK | Q06187 | 2/20 | 0.56 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | CIT | O14578 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7124677 | 0.88 | EGFR (0.73) | EGFRSRCKDRERBB2KIT | |
| Hydrochloric Acid SCHEMBL4373085 | 0.86 | SRC (0.72) | EGFRSRCKDRERBB2KIT | |
| SCHEMBL7127839 | 0.85 | SRC (0.54) | EGFRSRCKDRERBB2KIT | |
| SCHEMBL7127833 | 0.84 | EGFR (0.54) | EGFRSRCKDRERBB2KIT | |
| SCHEMBL8525415 | 0.83 | EGFR (0.64) | EGFRSRCKDRERBB2KIT | |
| SCHEMBL8490274 | 0.83 | EGFR (0.54) | EGFRKDRERBB2RETFLT1 | |
| Hydrochloric Acid SCHEMBL4379495 | 0.83 | SRC (0.74) | EGFRSRCKDRERBB2KIT | |
| SCHEMBL8525841 | 0.81 | EGFR (0.61) | EGFRSRCKDRERBB2KIT | |
| SCHEMBL7117613 | 0.79 | EGFR (0.58) | EGFRSRCKDRERBB2KIT | |
| SCHEMBL4371005 | 0.79 | RET (0.66) | EGFRKDRERBB2RETAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |