Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7120366 | 0.87 | EGFR (0.71) | EGFRERBB2KDR | |
| SCHEMBL7121754 | 0.84 | EGFR (0.54) | EGFRERBB2RETKDRFLT1 | |
| SCHEMBL7121759 | 0.83 | EGFR (0.53) | EGFRERBB2RETKDRFLT1 | |
| SCHEMBL8525865 | 0.83 | EGFR (0.57) | EGFRERBB2RETKDRFLT1 | |
| SCHEMBL8486258 | 0.82 | EGFR (0.60) | EGFRERBB2KDRHDAC3HDAC4 | |
| SCHEMBL8489385 | 0.80 | EGFR (0.57) | EGFRERBB2 | |
| SCHEMBL8142454 | 0.76 | EGFR (0.55) | EGFRERBB2KDRHDAC3HDAC4 | |
| SCHEMBL8151436 | 0.76 | EGFR (0.55) | EGFRERBB2KDRHDAC3HDAC4 | |
| SCHEMBL8488612 | 0.76 | EGFR (0.51) | EGFRRETKDRHDAC3HDAC4 | |
| SCHEMBL6098710 | 0.76 | RET (0.67) | EGFRERBB2RETKDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |