Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | HBB | P68871 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | FDPS | P14324 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8897388 | 0.90 | ALDH1A1 (0.54) | ALDH1A1NFKB1GPR84FFAR4FFAR1 | |
| SCHEMBL6383560 | 0.88 | ALDH1A1 (0.60) | ALDH1A1NFKB1GPR84FFAR4FFAR1 | |
| SCHEMBL6383565 | 0.88 | ALDH1A1 (0.60) | ALDH1A1NFKB1GPR84FFAR4FFAR1 | |
| Nitric Acid SCHEMBL8527457 | 0.85 | ALDH1A1 (0.59) | ALDH1A1NFKB1GPR84FFAR4FFAR1 | |
| SCHEMBL27548544 | 0.84 | ALDH1A1 (0.46) | ALDH1A1NFKB1GPR84FFAR4FFAR1 | |
| Nitric Acid SCHEMBL8584091 | 0.83 | ALDH1A1 (0.50) | ALDH1A1NFKB1GPR84FFAR4FFAR1 | |
| SCHEMBL8394901 | 0.82 | ALDH1A1 (0.50) | ALDH1A1NFKB1GPR84FFAR4FFAR1 | |
| SCHEMBL8905008 | 0.81 | ALDH1A1 (0.69) | ALDH1A1NFKB1GPR84FFAR4FFAR1 | |
| SCHEMBL6382144 | 0.81 | ALDH1A1 (0.63) | ALDH1A1NFKB1GPR84FFAR4FFAR1 | |
| SCHEMBL6379234 | 0.78 | ALDH1A1 (0.54) | ALDH1A1NFKB1GPR84FFAR4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952375-A | NEURAMINIDASE INHIBITOR FOR INHIBITION OF VIRUSES, IN PARTICULAR INFLUENZA VIRUSES; FDA ORANGE BOOK LISTED PATENT FOR OSELTAMIVIR PHOSPHATE | GILEAD SCIENCES, INC. (US) | 1999-09-14 | — | — | US | disclosed |
| US-5763483-A | NEURAMINIDASE INHIBITOR TREATING INFLUENZA VIRUS INFECTION; OSELTAMIVIR OR THE FREE ACID THEREOF; FDA ORANGE BOOK LISTED PATENT FOR OSELTAMIVIR PHOSPHATE | GILEAD SCIENCES, INC. (US) | 1998-06-09 | — | — | US | disclosed |