Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 9/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.51 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 3/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.41 |
| ▸ | TUBB | P07437 | 2/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.41 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.41 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8526328 | 1.00 | NFE2L2 (0.53) | NFE2L2PDGFRBPDGFRABIRC5RELA | |
| SCHEMBL8501972 | 0.80 | NFE2L2 (0.47) | NFE2L2PDGFRBPDGFRATUBB4ATUBB | |
| SCHEMBL8887518 | 0.80 | NFE2L2 (0.47) | NFE2L2PDGFRBPDGFRATUBB4ATUBB | |
| SCHEMBL8879268 | 0.78 | KMT2A (0.57) | PDGFRBPDGFRARELATUBB4ATUBB | |
| SCHEMBL8879272 | 0.78 | KMT2A (0.57) | PDGFRBPDGFRARELATUBB4ATUBB | |
| SCHEMBL9092449 | 0.78 | PDGFRB (0.48) | PDGFRBPDGFRABIRC5 | |
| SCHEMBL8896335 | 0.78 | PDGFRB (0.48) | PDGFRBPDGFRABIRC5 | |
| SCHEMBL29375750 | 0.76 | PDGFRB (0.54) | PDGFRBPDGFRABIRC5RELAKDM4E | |
| SCHEMBL8499693 | 0.74 | PDGFRB (0.52) | PDGFRBPDGFRAKDM4ENPC1ALDH1A1 | |
| SCHEMBL14077283 | 0.74 | PDGFRB (0.58) | PDGFRBPDGFRABIRC5RELAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | claimed |
| US-RE36256-E | ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | disclosed |