Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1055281 | 0.97 | HDAC6 (0.56) | HDAC6HTTPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL1055278 | 0.84 | HDAC6 (0.74) | HDAC6HTTPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL1608962 | 0.83 | HDAC6 (0.77) | HDAC6HTTPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL29424777 | 0.81 | HDAC6 (0.56) | HDAC6HTTPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL1299107 | 0.81 | HDAC6 (0.56) | HDAC6HTTPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL2355361 | 0.81 | HTT (0.55) | HDAC6HTTPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL5947 | 0.80 | KDM4E (0.53) | HDAC6HTTPOLBKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2348443 | 0.80 | HTT (0.55) | HDAC6HTTPOLBKMT2AKDM4E | |
| SCHEMBL1534628 | 0.80 | HTT (0.52) | HDAC6HTTPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL5770698 | 0.80 | HTT (0.55) | HDAC6HTTPOLBCTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807875-A | OBESITY THERAPY | DR. KARL THOMAE GMBH (DE) | 1998-09-15 | — | — | US | disclosed |