Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 12/20 | 0.42 |
| ▸ | CYP24A1 | Q07973 | 5/20 | 0.40 |
| ▸ | CYP27B1 | O15528 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | GC | P02774 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8529292 | 1.00 | VDR (0.42) | VDRCYP24A1CYP27B1MAPTNR1I2 | |
| SCHEMBL9009445 | 0.90 | VDR (0.41) | VDRCYP24A1MAPTNR1I2ABCB11 | |
| SCHEMBL8992982 | 0.90 | VDR (0.40) | VDRCYP24A1CYP27B1MAPTNR1I2 | |
| SCHEMBL8527414 | 0.90 | VDR (0.41) | VDRCYP24A1CYP27B1MAPTNR1I2 | |
| SCHEMBL8992758 | 0.89 | VDR (0.42) | VDRCYP24A1CYP27B1MAPTNR1I2 | |
| SCHEMBL9009438 | 0.88 | VDR (0.40) | VDRCYP24A1CYP27B1 | |
| SCHEMBL9009452 | 0.88 | VDR (0.40) | VDRCYP24A1MAPTNR1I2ABCB11 | |
| SCHEMBL9009408 | 0.87 | VDR (0.39) | VDRCYP24A1MAPTNR1I2ABCB11 | |
| SCHEMBL8529675 | 0.87 | VDR (0.39) | VDRCYP24A1CYP27B1MAPTNR1I2 | |
| SCHEMBL9009440 | 0.87 | VDR (0.45) | VDRCYP24A1MAPTNR1I2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647219-B1 | DERIVATIVES IN THE VITAMIN D SERIES MODIFIED AT THE 20 POSITION, A METHOD OF PREPARING SUCH DERIVATIVES, INTERMEDIATES USED IN THIS METHOD, PHARMACEUTICAL PREPARATIONS CONTAINING THE DERIVATIVES AND THEIR USE IN THE PREPARATION OF DRUGS | SCHERING AG (DE) | 1996-07-31 | — | — | EP | claimed |
| EP-0663902-B1 | 25-CARBOXYLIC ACID DERIVATIVES IN THE VITAMIN D SERIES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN THE MANUFACTURE OF MEDICINES | SCHERING AG (DE) | 1998-03-11 | — | — | EP | disclosed |
| US-5585368-A | SKIN DISORDERS | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-12-17 | — | — | US | disclosed |
| US-5583125-A | SKIN DISORDERS, ANTITUMOR AGENTS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-12-10 | — | — | US | disclosed |
| EP-0647219-B1 | DERIVATIVES IN THE VITAMIN D SERIES MODIFIED AT THE 20 POSITION, A METHOD OF PREPARING SUCH DERIVATIVES, INTERMEDIATES USED IN THIS METHOD, PHARMACEUTICAL PREPARATIONS CONTAINING THE DERIVATIVES AND THEIR USE IN THE PREPARATION OF DRUGS | SCHERING AG (DE) | 1996-07-31 | — | — | EP | disclosed |