SCHEMBL8529051

C=C1/C(=C/C=C2\CCC[C@]3(C)[C@@H](C(C)(C)/C=C/C(O)C(C)(C)OC(=O)OCC)CC[C@@H]23)C[C@@H](O[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)C[C@@H]1O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	VDR	P11473	14/20	0.40

▸	CYP24A1	Q07973	4/20	0.38

▸	CYP27B1	O15528	1/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL9261157	0.95	VDR (0.38)	VDRCYP24A1CYP27B1
SCHEMBL8526759	0.95	VDR (0.38)	VDRCYP24A1CYP27B1
SCHEMBL8526671	0.89	VDR (0.40)	VDRCYP24A1CYP27B1
SCHEMBL8526932	0.89	VDR (0.42)	VDRCYP24A1
SCHEMBL8995606	0.89	VDR (0.39)	VDRCYP24A1CYP27B1
SCHEMBL8995680	0.84	VDR (0.41)	VDRCYP24A1CYP27B1
SCHEMBL8995653	0.84	VDR (0.42)	VDRCYP24A1CYP27B1
SCHEMBL8529301	0.83	VDR (0.39)	VDRCYP24A1CYP27B1
SCHEMBL8526725	0.83	CYP24A1 (0.37)	VDRCYP24A1CYP27B1
SCHEMBL8612238	0.82	VDR (0.38)	VDRCYP24A1CYP27B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0663902-B1	25-CARBOXYLIC ACID DERIVATIVES IN THE VITAMIN D SERIES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN THE MANUFACTURE OF MEDICINES	SCHERING AG (DE)	1998-03-11	—	—	EP	disclosed