⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30854909 | 0.82 | KDM4E (0.65) | — | |
| SCHEMBL48109 | 0.82 | KDM4E (0.65) | — | |
| SCHEMBL10887191 | 0.79 | KDM4E (0.62) | — | |
| Hydrochloric Acid SCHEMBL5406891 | 0.79 | KDM4E (0.70) | — | |
| SCHEMBL4624372 | 0.79 | KDM4E (0.62) | — | |
| SCHEMBL10887236 | 0.79 | KDM4E (0.62) | — | |
| SCHEMBL8581488 | 0.79 | KDM4E (0.62) | — | |
| SCHEMBL6733907 | 0.79 | KDM4E (0.62) | — | |
| SCHEMBL11439787 | 0.79 | KDM4E (0.62) | — | |
| SCHEMBL9819340 | 0.79 | KDM4E (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3259246-B1 | DERIVATIVES OF SOBETIROME | UNIV OREGON HEALTH & SCIENCE (US) | 2023-03-22 | — | — | EP | disclosed |
| US-20200181103-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2020-06-11 | — | — | US | disclosed |
| US-10392356-B2 | Derivatives of sobetirome | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2019-08-27 | — | — | US | disclosed |
| CN-107848940-A | Sobeirome derivatives | 俄勒冈健康科学大学 | 2018-03-27 | — | — | CN | disclosed |
| US-20180057472-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2018-03-01 | — | — | US | disclosed |
| EP-3259246-A1 | DERIVATIVES OF SOBETIROME | Oregon Health & Science University (US) | 2017-12-27 | — | — | EP | disclosed |
| US-9701650-B2 | Derivatives of sobetirome | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2017-07-11 | — | — | US | disclosed |
| WO-2016134292-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2016-08-25 | — | — | WO | disclosed |
| US-20160244418-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2016-08-25 | — | — | US | disclosed |
| EP-0643689-B1 | IMPROVED PROCESS FOR THE SYNTHESIS OF (5R)-1,1-DIMETHYLETHYL 6-CYANO-5-HYDROXY-3-OXO-HEXANOATE | WARNER LAMBERT CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0643689-A1 | IMPROVED PROCESS FOR THE SYNTHESIS OF (5R)-1,1-DIMETHYLETHYL 6-CYANO-5-HYDROXY-3-OXO-HEXANOATE | WARNER-LAMBERT COMPANY (US) | 1995-03-22 | — | — | EP | disclosed |
| WO-1993007115-A1 | IMPROVED PROCESS FOR THE SYNTHESIS OF (5R)-1,1-DIMETHYLETHYL 6-CYANO-5-HYDROXY-3-OXO-HEXANOATE | WARNER-LAMBERT COMPANY (US) | 1993-04-15 | — | — | WO | disclosed |
| US-5155251-A | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate | WARNER-LAMBERT COMPANY (US) | 1992-10-13 | — | — | US | disclosed |