Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 6/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 3/20 | 0.45 |
| ▸ | PLK1 | P53350 | 3/20 | 0.45 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7131127 | 0.86 | NTRK1 (0.47) | KDRPDGFRBPDGFRAMAPTAPP | |
| SCHEMBL8508649 | 0.86 | RPS6KA3 (0.54) | PDPK1CHEK1RETMEN1KMT2A | |
| SCHEMBL8530158 | 0.85 | RET (0.45) | PDPK1RECQLCHEK1PLK4PLK1 | |
| SCHEMBL8301615 | 0.85 | TLK2 (0.58) | PDPK1KDRPDGFRBMAPTMEN1 | |
| SCHEMBL5728227 | 0.85 | CHEK1 (0.60) | KDRPDGFRBPDGFRAMAPTCHEK1 | |
| SCHEMBL5728224 | 0.85 | CHEK1 (0.60) | KDRPDGFRBPDGFRAMAPTCHEK1 | |
| SCHEMBL15503691 | 0.85 | CHEK1 (0.60) | KDRPDGFRBPDGFRAMAPTCHEK1 | |
| SCHEMBL8527796 | 0.84 | SYK (0.51) | PDPK1RECQLCHEK1MAP3K7TAB1 | |
| SCHEMBL1389087 | 0.84 | PDPK1 (0.50) | PDPK1KDRPDGFRBPDGFRAFLT1 | |
| SCHEMBL8530156 | 0.83 | PDPK1 (0.55) | PDPK1KDRPDGFRBPDGFRACHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | disclosed |
| EP-0752985-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-15 | — | — | EP | disclosed |
| WO-1996022976-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1996-08-01 | — | — | WO | disclosed |