Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 9/20 | 0.58 |
| ▸ | JAK3 | P52333 | 2/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | FCER2 | P06734 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8530207 | 0.88 | TLK2 (0.53) | TLK2JAK3 | |
| SCHEMBL8292593 | 0.88 | PDPK1 (0.58) | TLK2PDPK1FCER2SYKMEN1 | |
| SCHEMBL8526923 | 0.86 | GSK3B (0.51) | TLK2MEN1KMT2AGAAMAPK1 | |
| SCHEMBL8529758 | 0.85 | PDPK1 (0.52) | PDPK1MEN1KMT2AKDRPDGFRB | |
| SCHEMBL1389040 | 0.84 | TLK2 (0.55) | TLK2JAK3PDPK1FCER2SYK | |
| SCHEMBL7131127 | 0.83 | NTRK1 (0.47) | SYKPIM1MEN1KMT2AKDR | |
| SCHEMBL8508649 | 0.83 | RPS6KA3 (0.54) | PDPK1FCER2SYKMEN1KMT2A | |
| SCHEMBL8530158 | 0.83 | RET (0.45) | PDPK1SYKMEN1KMT2A | |
| SCHEMBL5728227 | 0.82 | CHEK1 (0.60) | TLK2MEN1KMT2AKDRPDGFRB | |
| SCHEMBL5728224 | 0.82 | CHEK1 (0.60) | TLK2MEN1KMT2AKDRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752985-B1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 1999-08-04 | — | — | EP | disclosed |
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | disclosed |