Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 4/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | TK2 | O00142 | 2/20 | 0.47 |
| ▸ | PGK1 | P00558 | 1/20 | 0.47 |
| ▸ | PGK2 | P07205 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8530540 | 0.88 | CYP2C19 (0.54) | SLC29A1ADORA2AADORA2BCYP2C19ADORA3 | |
| SCHEMBL9019466 | 0.87 | SLC29A1 (0.50) | SLC29A1ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL8530012 | 0.86 | ADORA2A (0.59) | SLC29A1ADORA2AADORA2BCYP2C19ADORA3 | |
| SCHEMBL8532515 | 0.85 | CYP2C19 (0.52) | SLC29A1ADORA2AADORA2BCYP2C19ADORA3 | |
| SCHEMBL17485744 | 0.83 | HINT1 (0.56) | ADORA2AADORA2BTK2 | |
| SCHEMBL8529895 | 0.83 | P2RY11 (0.54) | SLC29A1ADORA2AADORA2BCYP2C19ADORA3 | |
| SCHEMBL8529229 | 0.83 | HINT1 (0.59) | SLC29A1ADORA2AADORA2BCYP2C19ADORA3 | |
| Nelarabine SCHEMBL13575801 | 0.81 | CYP2C19 (0.71) | SLC29A1ADORA2AADORA2BCYP2C19ADORA3 | |
| Nelarabine SCHEMBL18321891 | 0.81 | CYP2C19 (0.71) | SLC29A1ADORA2AADORA2BCYP2C19ADORA3 | |
| Nelarabine SCHEMBL18820 | 0.81 | CYP2C19 (0.71) | SLC29A1ADORA2AADORA2BCYP2C19ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821236-A | Tumor treatment with arabinofuranosyl purine derivatives | GLAXO WELLCOME INC. (US) | 1998-10-13 | — | — | US | disclosed |
| US-5747472-A | ANTICARCINOGENIC AGENTS AND ANTITUMOR AGENTS | GLAXO WELLCOME INC. (US) | 1998-05-05 | — | — | US | disclosed |
| US-5492897-A | ANTITUMOR AGENTS, AUTOIMMUNE DISEASES | BURROUGHS WELLCOME CO. (141) (US) | 1996-02-20 | — | — | US | disclosed |
| US-5424295-A | Useful in treatment of varicella-zoster virus infections | BURROUGHS WELLCOME CO. (US) | 1995-06-13 | — | — | US | disclosed |