Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 4/20 | 0.49 |
| ▸ | CTSK | P43235 | 3/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 5/20 | 0.47 |
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28676764 | 1.00 | ACE (0.52) | ACEPTPN1CTSSCTSKCTSL | |
| SCHEMBL14164211 | 0.90 | TACR1 (0.52) | ACEPTPN1CTSSCTSKCTSL | |
| SCHEMBL6160719 | 0.90 | ACE (0.46) | ACEPTPN1CTSSCTSKCTSL | |
| SCHEMBL6160724 | 0.90 | ACE (0.46) | ACEPTPN1CTSSCTSKCTSL | |
| SCHEMBL6853465 | 0.89 | TACR1 (0.52) | ACECTSSCTSKCTSLMAPT | |
| SCHEMBL26996502 | 0.86 | MAPT (0.48) | ACECTSSCTSKCTSLMAPT | |
| SCHEMBL23127318 | 0.84 | ATM (0.56) | ACEPTPN1CTSSCTSKCTSL | |
| SCHEMBL28556906 | 0.84 | ATM (0.56) | ACEPTPN1CTSSCTSKCTSL | |
| SCHEMBL6854583 | 0.84 | MAPT (0.46) | CTSSCTSKCTSLMAPTKDM4E | |
| SCHEMBL27514965 | 0.84 | ACE (0.42) | ACEPTPN1CTSSCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804578-A | USEFUL FOR TREATING OSTEOPROSIS, CATABOLIC ILLNESS, IMMUNE DEFICIENCY, BONE FRACTURE, SHROT STATURE IN CHILDREN, OBASITY, SLEEP DISORDER, CACHEXIA AND PROTEIN LOSS DUE TO CHRONIC ILLNESS SUCH AS AIDS AND CANCER | MERCK & CO., INC. (US) | 1998-09-08 | — | — | US | disclosed |