Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA3 | P07451 | 3/20 | 0.38 |
| ▸ | CA4 | P22748 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL418863 | 0.78 | MAPT (0.50) | MCL1HPGDTSHR | |
| SCHEMBL12190304 | 0.77 | GUSB (0.46) | GUSBPGRCDK1CCNB1CCNA2 | |
| SCHEMBL2371939 | 0.77 | KMT2A (0.46) | GUSBPGRCDK1CCNB1CCNA2 | |
| SCHEMBL2371936 | 0.77 | GUSB (0.46) | GUSBPGRCDK1CCNB1CCNA2 | |
| SCHEMBL6259655 | 0.77 | MCL1 (0.66) | MCL1HPGDTSHRPOLB | |
| SCHEMBL11514167 | 0.76 | KMT2A (0.45) | GUSBPGRCDK1CCNB1CCNA2 | |
| SCHEMBL11514174 | 0.76 | CA12 (0.47) | GUSBPGRCDK1CCNB1CCNA2 | |
| SCHEMBL9577136 | 0.76 | POLB (0.54) | GUSBPGRCDK1CCNB1CCNA2 | |
| SCHEMBL10993966 | 0.74 | MEN1 (0.43) | MCL1CA12CA1CA2CA7 | |
| SCHEMBL6258831 | 0.74 | AKR1B1 (0.44) | MCL1PFKFB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716989-A | Bicyclo 3.3.0!octane derivatives, process for their production and their pharmaceutical use | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-02-10 | — | — | US | disclosed |
| EP-0474817-B1 | BICYCLO [3.3.0]OCTANE DERIVATIVES, PROCESS FOR PRODUCING THEM AND THEIR PHARMACEUTICAL USE | SCHERING AG (DE) | 1995-10-11 | — | — | EP | disclosed |
| EP-0474817-A1 | BICYCLO 3.3.)]OCTANE DERIVATIVES, PROCESS FOR PRODUCING THEM AND THEIR PHARMACEUTICAL USE. | SCHERING AG (DE) | 1992-03-18 | — | — | EP | disclosed |
| WO-1991014675-A1 | BICYCLO[3.3.)]OCTANE DERIVATIVES, PROCESS FOR PRODUCING THEM AND THEIR PHARMACEUTICAL USE | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1991-10-03 | — | — | WO | disclosed |