Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.60 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.60 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.60 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.60 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.60 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CTSD | P07339 | 2/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
| ▸ | BACE1 | P56817 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29602242 | 0.93 | KMT2A (0.67) | RENMEN1KMT2AATMACE | |
| SCHEMBL8130179 | 0.93 | KMT2A (0.67) | RENMEN1KMT2AATMACE | |
| SCHEMBL29484184 | 0.92 | KMT2A (0.66) | RENMEN1KMT2AATMPSEN1 | |
| SCHEMBL21244275 | 0.92 | REN (0.71) | RENMAPK1ACE | |
| SCHEMBL3499528 | 0.92 | REN (0.71) | RENMAPK1ACE | |
| SCHEMBL19341935 | 0.92 | REN (0.71) | RENMAPK1ACE | |
| SCHEMBL3824374 | 0.92 | REN (0.71) | RENMAPK1ACE | |
| SCHEMBL17629479 | 0.92 | REN (0.71) | RENMAPK1ACE | |
| SCHEMBL9101385 | 0.91 | REN (0.73) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3046634 | 0.91 | REN (0.73) | RENPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821331-A | INHIBIT THE PROTEOLYTIC ACTIVITY OF PROTEASES | ELI LILLY AND COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| US-5514778-A | ENZYME INHIBITORS OF PROTEOLYTIC ENZYMES FOR RHINOVIRUSES | ELI LILLY AND COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0632051-A1 | Anti-picornaviral agents | ELI LILLY AND COMPANY (US) | 1995-01-04 | — | — | EP | disclosed |