Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | MMEL1 | Q495T6 | 2/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8533383 | 0.98 | POLB (0.41) | POLBMAPTKDM4CKDM5AKDM5B | |
| SCHEMBL8530656 | 0.91 | MAPT (0.42) | MAPTKDM4CKDM5AKDM5BFFAR1 | |
| SCHEMBL8796844 | 0.84 | POLB (0.43) | POLBMAPTKDM4CKDM5AKDM5B | |
| SCHEMBL8532864 | 0.76 | CYP1A2 (0.40) | MAPTKDM4CKDM5AKDM5B | |
| SCHEMBL8797564 | 0.76 | MCL1 (0.46) | POLBMAPTFFAR1 | |
| SCHEMBL8528989 | 0.75 | CYP1A2 (0.41) | POLBMAPTKDM4CKDM5AKDM5B | |
| SCHEMBL8533380 | 0.73 | CYP2C9 (0.42) | POLBMAPTKDM4CKDM5AKDM5B | |
| SCHEMBL8532755 | 0.72 | CYP1A2 (0.43) | POLBMAPTKDM4CKDM5AKDM5B | |
| SCHEMBL8531978 | 0.69 | MCL1 (0.45) | — | |
| SCHEMBL8530651 | 0.68 | DHODH (0.45) | MAPTFFAR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773428-A | BONE DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0807114-A1 | BRIDGED INDOLES AS MATRIX METALLOPROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1997-11-19 | — | — | EP | disclosed |
| WO-1996023791-A1 | BRIDGED INDOLES AS MATRIX METALLOPROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-08-08 | — | — | WO | disclosed |