Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | STS | P08842 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NT5E | P21589 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11482830 | 0.94 | MAPT (0.62) | MAPTRAB9ANPC1STSTSHR | |
| SCHEMBL223335 | 0.87 | MAPT (0.75) | MAPTRAB9ANPC1STSALDH1A1 | |
| SCHEMBL11646587 | 0.84 | MAPT (0.72) | MAPTRAB9ANPC1STSALDH1A1 | |
| Hydrochloric Acid SCHEMBL4289450 | 0.84 | MAPT (0.72) | MAPTRAB9ANPC1STSALDH1A1 | |
| Hydrochloric Acid SCHEMBL4372451 | 0.84 | MAPT (0.72) | MAPTRAB9ANPC1STSALDH1A1 | |
| SCHEMBL3790067 | 0.80 | MAPT (0.67) | MAPTRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| Benzidine SCHEMBL9390356 | 0.80 | MAPT (0.67) | MAPTRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| Acetophenone SCHEMBL28341606 | 0.78 | MAPT (0.64) | MAPTRAB9ANPC1ALDH1A1SMN1; SMN2 | |
| Acetophenone SCHEMBL10453049 | 0.78 | MAPT (0.56) | MAPTRAB9ANPC1STSTSHR | |
| SCHEMBL28066023 | 0.77 | MAPT (0.62) | MAPTRAB9ANPC1STSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668274-B1 | Sulfonamidodioxepanes with hypoglycemic activity, methods of preparation, intermediates and salts thereof | PLIVA PHARM & CHEM WORKS (HR) | 1998-08-26 | — | — | EP | disclosed |
| EP-0668274-A1 | Sulfonamidodioxepanes with hypoglycermic activity, methods of preparation, intermediates and salts thereof | PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo (HR) | 1995-08-23 | — | — | EP | disclosed |