Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 11/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 6/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | RECQL | P46063 | 2/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.60 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817979 | 0.93 | POLB (0.79) | POLBGAAALDH1A1TDP1CYP3A4 | |
| SCHEMBL6813061 | 0.89 | MEN1 (0.65) | POLBGAAALDH1A1TDP1MAPT | |
| SCHEMBL11068320 | 0.81 | GAA (0.71) | POLBGAAALDH1A1CTDSP1MAPT | |
| SCHEMBL19034437 | 0.81 | ALDH1A1 (1.00) | POLBGAAALDH1A1TDP1CYP3A4 | |
| SCHEMBL11485510 | 0.79 | MEN1 (0.68) | POLBGAAALDH1A1TDP1CYP3A4 | |
| SCHEMBL11693391 | 0.79 | ALDH1A1 (0.66) | POLBGAAALDH1A1TDP1CYP3A4 | |
| SCHEMBL17512404 | 0.78 | POLB (0.70) | POLBGAAALDH1A1TDP1CTDSP1 | |
| SCHEMBL11316671 | 0.78 | SMN1; SMN2 (0.61) | POLBGAAALDH1A1TDP1MAPT | |
| SCHEMBL751204 | 0.78 | MAPT (0.69) | POLBGAAALDH1A1TDP1CYP3A4 | |
| SCHEMBL11957596 | 0.77 | ALDH1A1 (0.75) | POLBGAAALDH1A1TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042276-A1 | THIOUREA COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY LLC (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032433-A1 | THIOUREA AND BENZAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1999-07-01 | — | — | WO | disclosed |