Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8538019 | 1.00 | TDP1 (0.48) | TDP1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL8536763 | 0.99 | TDP1 (0.49) | TDP1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL8824695 | 0.81 | ALDH1A1 (0.55) | TDP1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL9303219 | 0.79 | ALDH1A1 (0.56) | TDP1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL1343553 | 0.76 | CCNE1 (0.52) | TDP1KDM4ESMN1; SMN2HDAC1LMNA | |
| SCHEMBL9716625 | 0.75 | KDM4E (0.44) | ALDH1A1HPGDHSD17B10KDM4ENPSR1 | |
| SCHEMBL2628001 | 0.75 | KMT2A (0.65) | ALDH1A1HPGDKDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL1340534 | 0.75 | EPHX2 (0.55) | ALDH1A1HPGDKDM4ETP53SMN1; SMN2 | |
| SCHEMBL29531243 | 0.74 | MAPK1 (0.50) | ALDH1A1HPGDSMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL1939816 | 0.74 | MAPK1 (0.50) | ALDH1A1HPGDSMN1; SMN2HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763437-A | Benzodiazepine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| EP-0804425-A2 | BENZODIAZEPINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996004254-A2 | BENZODIAZEPINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-15 | — | — | WO | disclosed |