Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 6/20 | 0.56 |
| ▸ | GRIA2 | P42262 | 6/20 | 0.56 |
| ▸ | GRIA3 | P42263 | 6/20 | 0.56 |
| ▸ | GRIA4 | P48058 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798182 | 0.82 | GRIA1 (0.47) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7103934 | 0.78 | GRIA1 (0.81) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL14287158 | 0.73 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8537048 | 0.73 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL29798454 | 0.72 | GRIA1 (1.00) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL678318 | 0.72 | GRIA1 (1.00) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6787042 | 0.69 | GRIA1 (0.52) | GRIA1GRIA2GRIA3GRIA4SMN1; SMN2 | |
| SCHEMBL6785459 | 0.69 | GRIA1 (0.57) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6780551 | 0.69 | GRIA1 (1.00) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7959740 | 0.67 | GRIA1 (0.87) | GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843945-A | AMPA antagonists and a method of treatment | NEUROSEARCH A/S (DK) | 1998-12-01 | — | — | US | claimed |
| US-5843945-A | AMPA antagonists and a method of treatment | NEUROSEARCH A/S (DK) | 1998-12-01 | — | — | US | disclosed |
| US-5780493-A | TREATING BRAIN DISORDERS | NEUROSEARCH A/S (DK) | 1998-07-14 | — | — | US | disclosed |